Endocrine Abstracts

Introduction: Vitamin D deficiency is a common health problem worldwide, particularly in elderly patients. Vitamin D is considered a key hormone in mineral and bone metabolism, as well as in functions such as the regulation of cell proliferation and differentiation, its immunoregulatory activity, its effect on the cardiovascular system and its neuroprotective and anti-ageing effects, among others. Hypovitaminosis D has been linked in multiple studies to a higher incidence and ...

Introduction and Objectives: Continuous glucose monitoring (CGM) has demonstrated benefits in the prevention of hypoglycemia in patients with type 1 diabetes mellitus (DM1) vs flash monitoring (CGM). Our aim was to analyze the clinical characteristics, indication and glucometric changes in patients using MFG after CGM implantation.Material and methods: Retrospective observational study of 13 patients under follow-up for DM1 in Endocrinology consultations...

Introduction: Hypophysitis is a rare disease. Lately, it is more frequent due to the use of Inmune Check Point Inhibitor (ICPIs). Ipilimumab or combo Ipilimumab + Nivolumab are the main cause. Agree with literature, 17-18% of the patients with these drugs suffer from. By contrast, with Idiopatic Autoimmune Hypophysitis and Lymphocytic Hypophysitis, this type of hypophysitis occurs in sixties men. Autoinmunity mechanism is known, but precise pathophysiology is unclear <p cl...

Introduction: Medullary thyroid carcinoma (MTC) arises from thyroid parafollicular C cells and accounts for <5% of thyroid cancers. Nearly 25% occur in the context of multiple endocrine neoplasia type 2 syndrome (MEN2) or familial isolated MTC.Objectives: Evaluation of clinical characteristics and evolution of patients with MTC.Methods: Retrospective analysis of clinical records of patients with MTC diagnosed from 2001 to 2023....

p53 family controls several metabolic and cellular functions. The p63 member regulates lipid metabolism in hepatocytes and contributes to the development of liver steatosis. Here we show that p63 plays an important role in liver fibrosis. P63 is upregulated in patients with NASH, correlating positively with fibrosis score and collagen 1a1 expression. P63 expression is also increased in different animal models of diet-induced NASH and chemically induced liver fibrosis. Mice wit...

Introduction / Background: Patients with advanced GEP-NENs often present with metabolic disorders and oncological treatments may increase malnutrition risk as well as alterations on body composition. Several studies have suggested that sarcopenia is independently associated with a worse prognosis in oncological patients. Sarcopenia predicts survival regardless of body weight; moreover, a reduced muscle mass is not only observed in cachectic individuals but also in overweight p...

Medical treatment of acromegaly is currently performed through a trial-error manner using somatostatin receptor ligands (SRLs) as first-line drugs. Average SRLs response is seen in 50% of cases; subsequent drugs are indicated following clinical judgement. Some biomarkers either before or after surgical failure have been reported to predict SRLs response, including intensity in T2 weighted MRI, short acute octreotide test (sAOT), and different molecules such as SST2 and E-cadhe...

Introduction: In many endocrine centres the 250μg Short Synacthen (Cosyntropin) Test (SST) is the reference standard for the diagnosis of adrenal insufficiency (AI) 1, but it is time consuming, expensive, and requires hospital attendance and venepuncture. The morning physiological peak of cortisol shortly after waking is a good predictor for a negative SST; however, a morning serum cortisol requires venepuncture. Serum cortisol and salivary cortisone correlate ...

Early diagnosis of CS could reduce the morbidity and mortality associated with endogenous hypercortisolism. Many clinical methods have been proposed to establish suspicion of CS, but they show a poor positive predictive value (PPV) and are sometimes difficult to assess. Assuming the well-known influence of hypercortisolism on white blood cell (WBC) count, we evaluated its potential usefulness as a screening test to trigger this suspicion. We analysed WBC count around the diagn...

Introduction: Simultaneous pancreas-kidney transplantation (SPKT) is the treatment of choice for type 1 diabetic patients with advanced kidney chronic disease (CKD), restoring normoglycemia, insulin independence and improving survival. The present study aims to analyse survival of patients undergoing SPKT and the post-SPKT metabolic profile of patients with a functioning pancreatic graft.Methods: Retrospective observational study. T1DM patients with CKD ...